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KMID : 0043320060290060479
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Archives of Pharmacal Research
2006 Volume.29 No. 6 p.479 ~ p.483
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Constituents from the Fruiting Bodies of Ganoderma applanatum and Their Aldose Reductase Inhibitory Activity
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Lee Sang-Hyun
Shim Sang-Hee
Kim Ju-Sun
Kang Sam-Sik
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Abstract
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Eight compounds were isolated from the fruiting bodies of Ganoderma applanatum, and were identified as 2-methoxyfatty acids (1), 5-dihydroergosterol (2), ergosterol peroxide (3) 3β,7β, 20,23ξ-tetrahydroxy-11,15-dioxolanosta-8-en-26-oic acid (4), 7β,20,23ξ-trihydroxy-3,11,15-trioxolanosta-8-en-26-oic acid (5), cerevisterol (6), 7β,23ξ-dihydroxy-3,11,15-trioxolanosta-8,20E (22)-dien-26-oic acid (7), and 7β-hydroxy-3,11,15,23-tetraoxolanosta-8,20E(22)-dien-26-oic acid methyl ester (8) by spectral analysis. All compounds were isolated for the first time from this fruiting bodies, and their effect on rat lens aldose reductase (RLAR) activity was tested. Among these eight compounds, ergosterol peroxide (3) was found to exhibit potent RLAR inhibition, its IC50 value being 15.4 μg/mL.
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KEYWORD
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Ganoderma applanatum, Polyporaceae, Ergosterol peroxide, Aldose reductase activity
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